Metabolic Research
Retatrutide — 10mg
$105
The 10mg vial format of retatrutide, Eli Lilly's triple GLP-1/GIP/glucagon receptor agonist, offering greater dosing flexibility for metabolic research protocols targeting weight loss, insulin resistance, and hepatic fat.
Metabolic ResearchOverview
Retatrutide 10mg provides the same triple-receptor agonist compound in a higher-quantity format suited to research protocols requiring extended administration windows or multi-subject study designs. The pharmacology is identical to the 8mg presentation: a 39-amino acid peptide with a C20 fatty diacid modification enabling albumin-mediated half-life extension and once-weekly subcutaneous delivery in clinical contexts.
The 10mg format is particularly practical for researchers conducting comparative efficacy studies across dose ranges, or for protocols designed to run parallel to the Phase 3 TRIUMPH clinical program. The compound's balanced GLP-1R, GIPR, and GCGR agonism makes it mechanistically distinct from both semaglutide and tirzepatide — a distinction that is experimentally meaningful when investigating the specific contribution of glucagon receptor activation to energy expenditure, hepatic lipid clearance, or anti-inflammatory effects in metabolic tissue.
Phase 3 TRIUMPH-4 results showing 28.7% mean weight loss at 68 weeks represent the most compelling clinical weight reduction data for any compound in this class. The 10mg vial ensures that research programs tracking these outcomes have adequate supply for the full arc of their protocols.
Mechanism of Action
Triple agonist at GLP-1R (appetite suppression), GIPR (insulin sensitization), and GCGR (hepatic lipolysis and energy expenditure); C20 fatty diacid modification enables once-weekly dosing via albumin binding.
Research Applications
Areas of peer-reviewed scientific inquiry where this compound has appeared.
- Obesity and adipose tissue research
- Type 2 diabetes and insulin resistance
- Knee osteoarthritis
- Obstructive sleep apnea
- Non-alcoholic steatohepatitis (NASH)
Key Findings from the Literature
- 01Phase 2: 24.2% mean weight loss at 48 weeks at highest dose
- 02Phase 3 TRIUMPH-4: 28.7% mean weight loss at 68 weeks
- 03Highest weight loss efficacy of any obesity pharmacotherapy in clinical trials to date
- 04Glucagon receptor agonism adds hepatic lipolysis absent from GLP-1-only agents
Certificates of Analysis2
Independent third-party lab reports for this peptide. Each CoA can be verified against its accession number at the testing lab.
2 independent tests by Freedom Diagnostics Testing
| Test | Result |
|---|---|
| Purity (HPLC) | 99.859% |
| Identity (MS) | Pass |
| Endotoxins (LAL) | Pass |
Lab: Freedom Diagnostics Testing
Accession: 2601220028 / 2601220029
Reports are verifiable against the issuing lab using the accession or batch identifier above.
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